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[75] [76] Results in primates suggest that acetylcholine is involved in the encoding of new information into long-term memory

Contraindications and precautions Consider avoiding DSIP or consulting a physician if: Pregnant or breastfeeding (insufficient safety data) Taking naloxone or other opioid antagonists (may block effects) Using medications metabolized by peptidases (potential interactions) History of immune disorders (theoretical immunogenicity concern) Already using multiple sleep medications Drug interactions Because DSIP degrades via amino-peptidases in blood, medications affecting these enzymes (like the ACE inhibitor captopril) could theoretically alter DSIP metabolism

It is critical to avoid freezing these medications, as freezing damages the molecular structure of the active ingredient, rendering the medication ineffective

While Dihexa is generally well-tolerated, some users report: These are typically dose-dependent and resolve with adjustment

K., & Morozov, V