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While mechanisms of resistance to Venetoclax that directly affect BCL-2 have been explored, changes influencing the cellular pharmacokinetics of BCL-2 inhibitors and their accumulation in leukemic target cells are largely unknown

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Uncoupled endothelial NOS, nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase, xanthine oxidase, and mitochondrial electron transport are the main sources of ROS