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Description

ROS and iron ions aggregate, the mitogen-activated protein kinase (MAPK) system is activated, cystine uptake is reduced, GSH is depleted, and system xc is inhibited (Shin et al., 2018)

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In Alzheimers disease models, it also upregulates endogenous antioxidative enzymes such as SOD and catalase, mitigating amyloid--induced oxidative injury (10)