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[2] General symptoms Fatigue, lethargy Increased susceptibility to infections [7] Organ-specific symptoms Liver Abdominal pain Hepatomegaly Cirrhosis Increased risk of hepatocellular carcinoma (common cause of death) [8] Pancreas: signs of diabetes mellitus (polydipsia, polyuria) Skin: : hyperpigmentation, bronze skin Pituitary gland: hypogonadism, erectile dysfunction, testicular atrophy, loss of libido, amenorrhea [9] Joints: : arthralgia (typically symmetrical arthropathy of the MCP joints II and III)

doi: 10.1016/j.envexpbot.2022.104854 102 WuX

Trimetazidine improved adriamycin-induced cardiomyopathy by downregulating TNF-, BAX, and VEGF immunoexpression via an antioxidant mechanism

70 Further research indicates that aside from inherent antimelanoma activity, NBDHEX also has the ability to enhance the function of temozolomide, with the two able to work synergistically to suppress tumor growth

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