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Targeting DHODH with AG-636 Induces Apoptosis and Differentiation and Inhibits Mitochondrial Function in AML, Translating into Anti-Tumor Efficacy in Vitro and in Vivo

It is plausible that GSTs serve two distinct roles in the development of drug resistance via direct detoxification as well as acting as an inhibitor of the MAP kinase pathway

Damage-associated molecular patterns (DAMPs) activate pattern recognition receptors, triggering the substantial release of pro-inflammatory cytokines (including IL-6, TNF-, and IL-1) and CXC chemokines 6

Notably, IL-6 not only modulates hepcidin to affect the release of stored iron from ATMs and intestinal absorption, but also reduces transferrin expression and aggravates iron accumulation by promoting hepcidin production

Bioavailability of quercetin is an important issue and a serious obstacle for its use in AD treatment