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The success of carnitine therapy in ischemic heart disease was first attributed to the higher in fat oxidation in cardiac myocytes, which resulted in an increased energy supply

Although the recommended dose can vary depending on the specific type of L-carnitine and individual needs, a general range of 500 to 4,000 mg (0.5 to 4 grams) per day is commonly used

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Another metabolically relevant compound that links carnitine and CoA derivatives is the malonyl-CoA that is required for fatty acid biosynthesis but acts as a potent inhibitor of the carnitine acyltransferases using cytoplasmic substrates, such as carnitine palmitoyltransferase 1 (CPT1), which is the first component of the mitochondrial carnitine shuttle (Ramsay and Arduini, 1993)

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