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Despite their benefits, weight gain, diabetes, metabolic syndrome, and cardiovascular disease are common side effects of this type of drugs, and insulin resistance that may be induced because of their use has been related to changes in DNA methylation, particularly with hypomethylation in fatty acyl CoA reductase 2 [246]

investigated the DNA methylation status of vimentin ( VIM ), demonstrating that its methylation levels increased during BLCA initiation and development [244]

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Aldonza et al., 2017[3]) to cancer cells has been shown to affect many molecular signaling pathways, especially detoxification mechanisms, leading to the development of cross- or multi-drug resistance

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