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48, 49 Several possible mechanisms by which advancing age impairs endothelial function are postulated (Figure 2)

Majumdar S, Srirangam R

Japonica 55 , 5155 (2013)

Hsiao, A

The production of SAMe can be interrupted by an excess of oxidative stress, sulfhydryl metals and endogenous toxins such as ethanol exposure (Waly et al., 2004)