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Mol Cell Biochem 357(12):227233

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In support with these results it has been shown that cellular starvation inhibits mTORC1 pathway, interestingly, it was shown that the cells show a mitochondrial elongation phenotype under starvation (128, 129) similar to that observed in asTORi treatment

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The 100 mg/kg bw/day used in the prevention study came about after an evaluation of the intervention study results and with the knowledge that Cremer, et al, [35], used up to 180 mg/kg bw/day for 24 months led to no observable effects of ALA on histology or pathology