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But in their purest form, they are anti-inflammatory and crucial for cellular health

Like normal HSCs, LSCs reside in the BM niche of AML patients (23) which supports their survival and protects them against chemotherapeutic drug treatment (2426)

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doi: 10.1016/j.jcin.2015.07.021 3

Indeed, the W34A mutation, which disrupts the ability of WW domain bind to a pSer/Thr-Pro motif 44 , prevented the PIN1 interaction with CDH1-WT (Supplementary Fig