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Hydroxy cobalamin and cyanocobalamin are physiologically active after being converted to methylcobalamin or 5-deoxyadenosylcobalamin

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Growth response to rhIGF-I 80 microg/kg twice daily in children with growth hormone insensitivity syndrome: relationship to severity of clinical phenotype

A course of four eye peels (7-21 days apart) is recommended

Comment: The applicant acknowledged that CMS applies a high evidentiary standard for substantial clinical improvement, typically requiring robust clinical data showing improved patient outcomes such as reduced complications, fewer reoperations, faster recovery, or better functional results compared to the current standard of care