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Notes that alternative pathways such as polyamine biosynthesis could compensate for raised SAM, that partial rather than total inhibition may be preferable to avoid compensatory mechanisms from an imbalanced SAM/SAH ratio, and that the consequences of sustained NNMT inhibition on systemic epigenetics remain unclear

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This review addresses some aspects of the organization of components of fat metabolism in the adipocyte, lipolysis and lipogenesis, and how genetic manipulation of the pathway of lipolysis affects fat metabolism in the adipocyte

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