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Although no direct ligand has been identified for HER2/neu, it can be activated through overexpression or transactivation by ligands of other EGF family receptors (60, 61) In addition, the phosphatase protein tyrosine phosphatase 1B (PTP1B) regulates tyrosine kinase signalling by dephosphorylating key kinases involved in breast tumourigenesis, including HER1/EGFR, proto-oncogene tyrosine-protein kinase (Src), janus kinase (JAK), and signal transducer and activator of transcription (STAT)

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During ferroptosis, autophagy facilitates the production of free iron by affecting the levels of iron input and output, storage, and transport [99, 100, 120]

Intranasal Delivery of Proteins and Peptides in the Treatment of Neurodegenerative Diseases

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