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A similar observation was reported for an engineered -wrapin, which binds the highly hydrophobic pre-NAC region of Syn and inhibits its aggregation 68,75,76

G.AbellC

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In response to nutrient abundance, mTORC1 phosphorylates TFEB at the lysosomal membrane, thereby inhibiting its migration to the nucleus and promoting its retention in the cytosol in an inactive state (Tong and Song, 2015