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Acyltransferases mediating butyrylation exhibited distinct substrate specificities: in vitro studies demonstrated that CBP/p300 (CREB-binding protein/E1A binding protein p300) directly butyrylates both histone H4 and non-histone protein p53 [58], whereas Gcn5 mutation significantly reduced histone H3 butyrylation [60]

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This positive correlation, previously reported in literature, is likely to reflect the improved protein retention leading to increased body mass [52]

Its main job is to act as a cellular bodyguard