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Moreover, emerging mechanistic and clinical evidence published in recent years has not yet been comprehensively integrated

Key gaps include limited human RCTs for mechanism validation, overlooked microbiota-nutrient bidirectional interactions, and lack of personalized strategies

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Viallard C, Larrive B

This is due to more steps being required in manufacturing purified proteins compared to that of small molecule drugs ( Future directions Due to the imperfect therapeutic efficacy and the extremely high costs associated with current treatments, there is a pressing need for novel therapeutics