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Next, cells were treated with DMSO and sertraline for 48 h, reaching a DMSO concentration of 0.1%

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A systematic review of behavioral and exercise interventions in prevention and management of CIPN concluded that exercise interventions are likely beneficial, but recommended additional, high-quality studies in this area

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However, some users report cardiovascular effects including rapid heartbeat, chest pain, or dizziness, particularly with excessive application or use on compromised skin barriers