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243 In AML, the level of H3K36me3 changes most dramatically before and after Met deprivation, and inhibition of STED2, the H3K36-specific methyltransferase, can reproduce most of the cytotoxic phenotypes produced by Met deprivation

This influence may be at least partly related to oxidative stress, since smoking habit decreases factors related to antioxidant capacity, such as uric acid 5

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doi: 10.1128/mBio.01713-16 105

[DOI] [PubMed] [Google Scholar] 94.Laughner E., Taghavi P., Chiles K., Mahon P.C., Semenza G.L