glutathione peroxidase 1 pathway Frontiers The Role of Glutathione Peroxidase-1

So June and May share 11 months of identical data, with one new month added, and the oldest month lopped off

Key mitochondrial and antioxidant molecules such as Cytochrome c, UCH-L1, and thioredoxin domain-containing protein 12 were significantly downregulated

Peroxides generated during the process of metabolism, get eliminated by GPx and GST

The lack of robust clinical evidence limits their use in clinical practice

To address these limitations, future research should prioritize: (1) developing more physiologically relevant preclinical models (e.g., humanized liver chimeras, diet-induced murine models with metabolic comorbidities) to better recapitulate human NAFLD pathophysiology