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For HT, particularly non-celiac HT, the evidence favors selective screening and personalized counseling rather than blanket dietary restriction ( Future studies should prioritize well-powered randomized trials, better phenotyping of gluten-related subgroups, and integrated multi-omics approaches that can test whether gut, immune, and thyroid signals converge in clinically meaningful ways

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Despite melatonin treatment generally being ineffective in some patients, it remains worthy of further investigation due to its distinct functions in regulating circadian rhythms and mitigating oxidative stress

Nat Rev Drug Discov 5, 493506 (2006)

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