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Here, we investigate whether bepirovirsen is unique in its mechanism for innate immune activation compared to other ASOs, and whether presence of HBV mRNA via infection alters innate activity in the hTLR8 transgenic mouse model

The tumor suppressor p53 and its downstream targets regulate ferroptosis, which is another significant mechanism

doi: 10.3390/pathogens3010014 170 RodriguezCMayoJCSainzRMAntolnIHerreraFMartnVet al

One of these being from Choi et al

Consequently, this review examines the distinct autophagic roles of astrocytes, oligodendrocytes, and microglia, and delineates how these processes influence the pathology of major neurodegenerative disorders, including AD, PD, HD, and ALS