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PMID: 38106234

Abnormal DNA methylation typically occurs in the early stages of tumorigenesis and can provide new insights for the early detection of LC

In all three groups, 60% of participants had a low education level (elementary school only), 47% were smokers or ex-smokers, only 3% drank alcohol, 73% had hypertension and 52% had altered glucose (Table 2)

Additionally, ROS can activate Ras proteins, which, as GTPase switch proteins, activate Raf kinase and initiate a MAPK cascade, activating downstream kinases MEK and ERK