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Moreover, cGAS-driven micronucleophagy also dampens cGAMP production and altogether exerts a negative effect on cGAS-STING signaling and innate immunity (155)

Patients with DPYD gene mutations are at risk of life-threatening toxicity even at standard doses, including severe neutropenia, mucositis, and gastrointestinal bleeding

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Polymorphic deletion of three intracellular acidic residues of the 2B -adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization