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Imaging flow cytometry for multiparametric analysis of molecular mechanism involved in the cytotoxicity of human CD8(+) T-cells

How does insulin signaling interfere with FOXO4-DRI efficacy

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1) Reveal the hypoxia mechanism of RA tissues and cells: Through single-cell sequencing, proteomics, and gene knockout technology, the interaction mechanism of HIF-1 on downstream signaling pathways and its temporal and spatial dynamic changes in the hypoxic microenvironment of RA was deeply explored, which provided a new perspective and new ideas for the development of new diagnostic biomarkers and the determination of new therapeutic targets