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The rs738409 G allele is the strongest genetic determinant of MASLD risk

Indeed, it is intriguing to speculate that the clinical benefit of sorafenib observed in patients may be due, at least in part, to the activation of ferroptosis in vivo [28]

Analyzing sub-sequential molecular events related to the injury toward hepatocytes, alcohol stimulates the activity of cytochrome P450 enzymes, which contribute to ROS production, and reduces the levels of the antioxidant system (Wu and Cederbaum, 2003)

Sperm cells are particularly susceptible to oxidative and reductive imbalances because of their structural features, which include a high membrane concentration of polyunsaturated fatty acids, weak antioxidant defenses, and rapid metabolic activity [4]

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