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Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency

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This nutrient plays a crucial role in the synthesis of DNA, which is necessary for the formation of new cells, including red blood cells

Clinical Manifestations of Vitamin B12 Deficiency Although the classic hematologic expression of vitamin B 12 deficiency is a megaloblastic macrocytic anemia characterized by an elevated mean corpuscular volume and mean corpuscular hemoglobin, and a peripheral smear containing macroovalocytes and hypersegmented neutrophils, up to 28 percent of affected patients may have a normal hemoglobin level, and up to 17 percent may have a normal mean corpuscular volume

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