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Regarding traumatic brain injury, Zhang and associates [155,163,164] assessed spatial memory in rats using the Morris water maze test and demonstrated that PQQ administered intraperitoneally three days before injury improves spatial memory

Furthermore, the specific microbial taxa and their metabolites that control hepatic hepcidin production need to be identified and signaling by SCFAs, bile acid metabolites (BAM), or tryptophan metabolites examined in particular as to which of these are key signaling molecules in this axis