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Notably, these proteins have a close relationship with high-density lipoprotein particle, response to estrogen, response to estradiol, exopeptidase activity, and peptidase activity (Figure 2E, see also Supplementary Tables S4S6)

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In the context of 4-HNE, it has been suggested that this electrophile accumulates in membranes at concentrations of between 10 M to 5 mM following oxidative insult 57