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10.2147/OAEM.S24962 50 KangA

Moreover, as microorganisms consume O 2 during their growth, chronic wounds become increasingly hypoxic, limiting cellular energy production and impairing the activity of essential growth factors required for tissue regeneration [56]

The mechanism by which glutathione protects against enzymatic browning and reduces oxygen consumption is probably its capacity to combine with the orthodiquinones formed by the action of the polyphenol oxidases in stopping the browning process and depleting the medium on substrates for these enzymes