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The shift from maternal to embryonic regulation of development is supported by a closely controlled change in the short RNA landscape, which is reflected in this dynamic turnover [261], reduced number of hatched and unbroken blastocysts and elevated expression of Let-7a till the 8-cell stage [262], higher levels of miR-130a and miR-21 expression in zygotes compared to 8-cell stage embryos [263], In bovine embryos, elevated expression of several microRNAs, such as miR-205, miR-150, miR-96, miR-122, miR-146a, miR-145, miR-208, and miR-496, coincides with the minor and major embryonic genome activation