methylglyoxal glutathione reductase Model illustrating the metabolism and detoxification redox assays Research area Frontiers | Methylglyoxal, the dark

Simulations suggest that glutathione pools are most sensitive to exposure duration at pharmacologically and supra-pharmacologically relevant doxorubicin concentrations

doi:10.1111/j.1472-8206.2008.00638.x, PMID: 19207541 Kumar A, Garg R (2008) Kumar P (2008) Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome

L-theanine is a calming amino acid found mostly in green tea, black tea, white tea and matcha

By the end of January 2020, 2,500 cases of Middle East respiratory syndrome and more than 800 associated deaths (casefatality rate ~34%) were reported worldwide 8

3 Oxidative Stress Is Higher When Glutathione Runs Low Lower glutathione levels are associated with increased oxidative stress, placing additional strain on detox and cellular processes like methylation