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Nevertheless, although the inability to precisely deliver RNA-based tools remains a major barrier to developing RNA therapies, new RNA-based modalitiesparticularly CRISPR/Cas9-based gene editingwill likely gain considerable traction in the near future

For those inclined, the natural therapies outlined here offer an integrated approach that may improve myocardial bioenergetics, left ventricular function, and quality of life even when added to standard therapies of HF.