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Koutsompina ML, Pappa M, Sakellariou S, Gialouri CG, Fragoulis GE, Androutsakos T (2021) Methotrexate-related liver cirrhosis in psoriatic arthritis: a case report and review of the literature

Note that glutathione reduction occurs at roughly middle age and that the increase in free radicals is delayed but obvious

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Furthermore, comprehensive reviews of antioxidant therapies have emphasized the relevance of catalase and other ROS-scavenging enzymes in mitigating the molecular cascades triggered by oxidative and nitrosative stress during sepsis (Kumar et al., 2022