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Whether sublingual delivery actually produces meaningfully different exposure than oral hasnt been studied in humans

This phenomenon, known as metabolic endotoxemia, has been linked to: Chronic inflammation Insulin resistance Obesity Metabolic syndrome In animal studies, even modest increases in circulating endotoxins have been shown to trigger inflammatory responses that interfere with metabolic regulation

Ministry of Health, Singapore

doi:10.1016/j.bcp.2018.05.003 Neelakantan H, Brightwell CR, Graber TG, et al

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