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Thus, it is important to bear in mind that disruptions of cell physiology in response to perturbations in the Trx or GSH pathways, in particular in whole animals or other complex systems, is not necessarily indicative of a replicative block, and these distinctions can sometimes be difficult to tease apart experimentally

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In this condition, even with cortisol circulating, the immune system continues to produce inflammatory cytokines, including interleukin-6 (IL-6), interleukin-1 (IL-1), and tumor necrosis factor- (TNF-) as described by Miller et al