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mtDAMPs activate neutrophils and monocytes, which infiltrate tissues and release additional ROS and proteases, causing further mitochondrial damage and cell death

The Journal of clinical endocrinology and metabolism 99 , E13061310, (2014)

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A large amount of evidence shows that compared with single drug therapy, multi-drug combination therapy can enhance efficacy and reduce toxicity, achieve the same or better therapeutic effect without increasing drug dosage, and effectively reduce the development of drug resistance [181]