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doi: 10.1074/jbc.M211558200 117 LehrmannE.ChristensenT.ZimmerJ.DiemerN

J.SlavinJ

Nature 557 , 5056

10th ed

Despite the established efficacy of sorafenib and regorafenib in advanced HCC, resistance frequently develops with prolonged use, adversely influencing the subsequent course of the disease [88]