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VEGFR1 and -R2, AKT and ERK1/2, followed by a notable decrease in tumor cell proliferation (Ki67 expression) and angiogenesis (expression of CD31 and CD34), and also caused promotion of apoptosis (increased TUNEL staining and P53 expression and decreased Bcl-2 expression) and a significant decrease in metastasis-related factors (increased E-cadherin and decreased N-cadherin, NF-B and MMP-9 expression)

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TB-500 provides systemic healing support through enhanced cell migration, angiogenesis via VEGF and HIF-1 alpha pathways, and inflammation reduction through microRNA-146a upregulation