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Although ( by that time) has been first described in 1935 by Hall and OToole as part of the bacterial flora of the meconium and faeces of infants [4], it was only in 1974 that three independent studies have implicated has an important cause of disease in humans

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There is clear evidence that the gut microbiota directly influences UC occurrence, and the abnormal intestinal mucosal barrier will change the composition of pathogenic microorganisms, toxicity and invasiveness, and further aggravate inflammation