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The potential mechanism of KD is to reduce the availability of glucose to tumor cells, depriving them of energy, inhibiting their proliferation, and tumor growth (13, 20, 82)

New challenges to study heterogeneity in cancer redox metabolism

10.1080/14737175.2018.1400909 Expert Rev

[7] [8] NAD+ and NADH are continuously recycled during redox reactions, but during other metabolic activities, they are absorbed by NAD+-dependent enzymes and may subsequently become depleted over time, increasing the risk of DNA damage, age-related illnesses, and mitochondrial malfunction