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Quaternization or grafting with hydrophilic polymer molecules are popular chemistry modifications proposed to overcome this challenge and boost solubility and lifespan under physiological conditions (Pathak et al., 2021)

However, mesalazine suppositories are the first-line therapy for proctitis, a disease confined to the rectum that is common in people with UC and CD[24]

Preclinical research suggests it remains effective even at very low doses, with no significant toxicity observed in animal studies

Griffioen AW, Damen CA, Martinotti S, Blijham GH, Groenewegen G

Transfection of cells, Immunofluorescence microscopy and Subcellular fractionation of transfected cells For subcellular fractionation, HEK293T cells originating from ATCC (CRL-3216) were transfected using Ca-phosphate precipitation method