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Both the ACE2 receptor and TMPRSS-2 gene are expressed on endothelial cells and likely explain why COVID-19 infection produces widespread ED (79)

Assessment of intracellular redox status can be accomplished by a variety of methods, each offering unique advantages

Critically, in vitro binding or degradation does not guarantee efficacy in vivo due to the complex gastrointestinal environment, including variable pH, proteolytic enzymes, bile salts, and competition from resident microbiota (30, 94)

Furthermore, as sporadically shown for some rRFs (Son et al, 2013

For example, when using an 800-nm wavelength as the excitation light source, a 400-nm wavelength, which is weaker, is also present and excites the CDs simultaneously