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Description

Drugs with a Vd value of less than 0.3 L/kg are predominantly confined to the ECF, whereas drugs with a Vd value of greater than 1 L/kg are highly lipid soluble and tend to distribute out of the extracellular fluid and into tissue compartments (Box 4-1)

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PMID: 8 HuangS-FXuJ-LRenC-HSimNHanCHanY-Qet al

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Activity of cytotoxic lymphocytes in the tumor may also be antagonized due to the abnormal nature of tumor vasculature (107109)

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