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10.3390/cancers12082098 77 RohdewaldP

The molecular mechanisms associated with nutrient deficiencies (e.g., genes regulating nutrient transport and antioxidant metabolism) are included in Table 3A

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Thus, under circumstances of SAM excess homocysteine cannot be catabolized to cysteine and accordingly accumulates as cystathionine in brain ( There is also evidence for additional regulatory mechanisms for the co-ordination of remethylation and transsulfuration