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This observation, combined with evidence that older adults have blunted MOTS-c responses to exercise, supports the hypothesis that declining mitochondrial peptide signaling contributes to the reduced exercise adaptability seen in aging

Inflammatory conditions such as rheumatoid arthritis and lupus further elevate risk by causing chronic joint inflammation, which weakens the supportive structures around the big toe

Schneider WM, Chevillotte MD, Rice CM

Li N, Li X, Ding Y, Liu X, Diggle K, Kisseleva T, Brenner DA

Blocking the biological activity of IL-18 in mice by IL-18 binding protein (a natural antagonist of IL-18), can ameliorate APAP-induced acute liver injury [181]