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Pyruvate kinase isozyme M2 (PKM2) is one of the enzymes which are activated by the IGF-1/AKT axis [54, 55] (Fig

ITCs are among the major toxic hydrolysis products derived from most aliphatic GSLs 11

80,83 Recent studies have shown that metformin, by activating the AMPKSIRT2 axis, restores the expression of key glycolytic enzymes suppressed by insulin, thereby enhancing glycolytic flux in ovarian granulosa cells