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GMSCs encapsulated in the methacrylated 3D-collagen hydrogel were co-cultured with THP-1-derived macrophages, and the secretion of anti-inflammatory cytokine IL-10 or inflammatory cytokines TNF- and IL-1 in the supernatant was determined by ELISA

The subsequent disruption of the IEB allows the passage of antigens into the mucosa leading to further inflammation

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Combining retatrutide with another GLP-1 agonist (semaglutide, tirzepatide) is not recommended because the receptor overlap increases side effects without proportional benefit

Skin appendages were also involved, evidenced by hair follicle and eccrine coil necrosis