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doi:10.1016/j.mayocp.2020.08.034 Saber H, Yakoob MY, Shi P, et al

It works by inhibiting NNMT, the enzyme that methylates nicotinamide and reduces NAD+ availability

NNMT overexpression has been associated with metabolic dysfunction, obesity, and reduced NAD+ availability

Some users also introduce AOD-9604 during the early phase of Retatrutide dose escalation to give fat loss a head start while Retatrutide builds to its full therapeutic dose