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Interstitial delivery Drug delivery through intrathecal and intracerebroventricular strategies elude the BBB to some point, the direct administration of therapeutic drugs into the interstitium is the most direct strategy of brain targeting delivery systems [168]

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This microorganism is responsible for a broad spectrum of diseases, ranging from mild infections such as otitis media and sinusitis to severe conditions including meningitis, pneumonia, and bacteremia [1]

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