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To date, five L1 GUS enzymes, Ec GUS, Eubacterium eligens GUS ( Ee GUS), Streptococcus agalactiae ( Sa GUS), Clostridium perfringens GUS ( Cp GUS), and Faecalibacterium prausnitzii ( Fp GUS) have exhibited activity with p NPG, and all have been structurally characterized, with the exception of Fp GUS 17,20,21

1 Introduction Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common chronic inflammatory disease that results in impaired quality of life and a heavy economic burden ( Oxidative stress is an imbalance between the production of free radicals and their elimination by an organisms antioxidant system ( An increasing number of studies have shown that antioxidant therapeutic strategies are beneficial for the treatment of diabetes, coronary artery disease and neurological disorders ( 2 Materials and methods 2.1 Patients and tissue samples Nasal polyp samples from CRSwNP patients were obtained through functional endoscopic sinus surgery at the Department of Otolaryngology Head & Neck Surgery, West China Hospital, Sichuan University

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